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Abstract: 167-1

167-1

Comparative Computational Analysis of Dose Distributions in Prostate Brachytherapy Considering Different Source Types

Authors:
Leonardo Levy dos Santos (PPGEB-UFU - Programa de Pós-graduação em Engenharia Biomédica, Faculdade de Engenharia Elétrica, Universidade Federal de Uberlândia – Uberlândia, Brasil) ; Karen Leite Machado (PPGEB-UFU - Programa de Pós-graduação em Engenharia Biomédica, Faculdade de Engenharia Elétrica, Universidade Federal de Uberlândia – Uberlândia, Brasil) ; Guilherme Brilhante Guimarães (PPGEB-UFU - Programa de Pós-graduação em Engenharia Biomédica, Faculdade de Engenharia Elétrica, Universidade Federal de Uberlândia – Uberlândia, Brasil) ; William de Souza Santos (PPGEB-UFU - Programa de Pós-graduação em Engenharia Biomédica, Faculdade de Engenharia Elétrica, Universidade Federal de Uberlândia – Uberlândia, Brasil, DFI-UFS - Departamento de Física, Universidade Federal de Sergipe – São Cristóvão, Brasil) ; Lucio Pereira Neves (PPGEB-UFU - Programa de Pós-graduação em Engenharia Biomédica, Faculdade de Engenharia Elétrica, Universidade Federal de Uberlândia – Uberlândia, Brasil, INFIS-UFU - Instituto de Física, Universidade Federal de Uberlândia – Uberlândia, Brasil) ; Ana Paula Perini (PPGEB-UFU - Programa de Pós-graduação em Engenharia Biomédica, Faculdade de Engenharia Elétrica, Universidade Federal de Uberlândia – Uberlândia, Brasil, INFIS-UFU - Instituto de Física, Universidade Federal de Uberlândia – Uberlândia, Brasil)

Abstract:

Prostate cancer is among the most common cancers worldwide [1]. Metabolic syndrome, obesity, and smoking are regarded as potential modifiable risk factors to prostate cancer [1]. Patients diagnosed with localized prostate cancer have various treatment options, including radical prostatectomy, external beam radiotherapy, brachytherapy, androgen deprivation therapy, or combinations of these treatments. Among these treatment forms, the American Brachytherapy Society has affirmed that brachytherapy is a convenient, effective, and well-accepted treatment for localized prostate cancer [2].  The objective of this work was to computationally evaluate the doses received in the organs/tissues during high-dose-rate (HDR) brachytherapy for prostate cancer, using Iridium-192 and Cobalt-60 sources. The sources considered in the simulation were: Eckert & Ziegler BEBIG HDR Cobalt-60 model Co0.A86 source and Nucletron HDR Iridium-192 model mHDR-v2r source. Both Cobalt-60 and Iridium-192 are high-energy photon-emitting brachytherapy sources, each with distinct energy spectra. Iridium-192 has a mean photon energy of 0.355 MeV, while Cobalt-60 has a mean photon energy of 1.253 MeV [3]. For the simulation, the MCNP Monte Carlo code, version 6.2 [4], and two virtual anthropomorphic phantoms with different body mass indices (BMI) to represent two patients were utilized. Patient 1 has a BMI of 21.2 kg/m², with a mass of 59.3 kg and a height of 167.3 cm. Patient 2 has a BMI of 31.5 kg/m², with a mass of 108.5 kg and a height of 185.6 cm [5]. The results provided an isodose map, providing dose values for several organs near the target volume. They also indicated that a Cobalt-60 radionuclide source may be an alternative to the Iridium-192 radionuclide sources in HDR brachytherapy, based on the dose results in organs/tissues surrounding the prostate.

Acknowledgments:

The authors would like to thank the Brazilian agencies CNPq (Grants 312160/2023-2 (L.P.N), 312124/2021-0 (A.P.P), 309675/2021-9 (W.S.S) and 406303/2022-3), FAPEMIG (Grants APQ-04215-22, APQ-01254-23 and APQ-04348-23). This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) – Finance Code 001.

Keywords:
 Brachytherapy, Prostate, Monte Carlo