According to national and international regulations, certain groups and subgroups of Healthcare Waste need to undergo some type of treatment in order to reduce or eliminate the load of pathogens present before being disposed of in landfills, in order to avoid risks human health and the environment [1]. The pathogens present in infectious Healthcare Waste can be effectively inactivated by the application of ionizing radiation, provided that the minimum required amount of dose is homogeneously delivered to the packaged material containing the Healthcare Waste [2]. In the present project, the Monte Carlo computational simulation was carried out with x-ray and electrons beams, both with energy produced by industrial accelerators, from the irradiation of the packages containing Healthcare Waste. The stoichiometric chemical composition and proportions, the KERMA-fluence and Mass Stopping Power coefficients of Healthcare Waste were previously evaluated [3],[4]. The technical information of the industrial accelerators , such as: energy of beam, gun current, dose rate, distance from the beam outlet to the package and size of the irradiation field were set . The computational simulations of the irradiation processes of the Healthcare Waste packages were based on the MCNP [5]. The analysis of the homogeneity of the minimum absorbed dose for the pathogenic inactivation in the entire content was achieved. The present methodology supported the treatment of Healthcare Waste with industrial irradiation.